The state Transport department in a statement said that the order was issued following a meeting between Chief Minister Lal Thanhawla and leaders of the central committee of Young Mizo Association (YMA).
YMA leaders had requested Lal Thanhawla to take a tough stand against not only drug traffickers and pushers, but also the transporters.
The chief minister had in turn promised more stringent punishment would be meted out to vehicle owners and drivers involved in drug trafficking.
Transport department officials said majority of drugs in the state, including heroin and methamphetamine, are smuggled in from Myanmar via Zokhawthar along the international border in Champhai district.
The government has instructed police, transport, excise and narcotics departments' officials to keep watch on vehicles plying between Zokhawthar and Aizawl.
"There are 83 maxicabs plying between Zokhawthar and Aizawl carrying passengers, baggage and goods and a plethora of contraband haul were made from the vehicles plying in the route," the Transport officials said.